Polymorphism of the Flap Endonuclease 1 Gene in Keratoconus and Fuchs Endothelial Corneal Dystrophy

Polymorphism of the Flap Endonuclease 1 Gene in Keratoconus and Fuchs Endothelial Corneal Dystrophy

Oxidative stress is implicated in the pathogenesis of many diseases, including serious ocular diseases, keratoconus (KC) and Fuchs endothelial corneal dystrophy (FECD). Flap endonuclease 1 (FEN1) plays an important role in the repair of oxidative DNA damage in the base excision repair pathway. We de...

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Bibliographic Details
Main Authors: Katarzyna A. Wojcik, Ewelina Synowiec, Piotr Polakowski, Sylwester Głowacki, Justyna Izdebska, Sophie Lloyd, Dieter Galea, Janusz Blasiak, Jerzy Szaflik, Jacek P. Szaflik
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:International Journal of Molecular Sciences
Subjects:
keratoconus
Fuchs endothelial corneal dystrophy
flap endonuclease 1
DNA repair
Online Access:http://www.mdpi.com/1422-0067/15/8/14786

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