Development of functional human NK cells in an immunodeficient mouse model with the ability to provide protection against tumor challenge.

Development of functional human NK cells in an immunodeficient mouse model with the ability to provide protection against tumor challenge.

Studies of human NK cells and their role in tumor suppression have largely been restricted to in vitro experiments which lack the complexity of whole organisms, or mouse models which differ significantly from humans. In this study we showed that, in contrast to C57BL/6 Rag2(-/-)/gamma(c) (-/-) and N...

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Bibliographic Details
Main Authors: Amanda Kwant-Mitchell, Elishka A Pek, Kenneth L Rosenthal, Ali A Ashkar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2793015?pdf=render

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