Expression of MAGE-A12 in Oral Squamous Cell Carcinoma
Melanoma associated-A antigens (MAGE-A) are silent in normal tissues except testis. However, they are activated in a variety of different tumors. Thus, their expression is highly specific to cancer cells. Reverse transcription-nested polymerase chain reaction (RT-nPCR) is a highly sensitive techniqu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2008-01-01
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| Series: | Disease Markers |
| Online Access: | http://dx.doi.org/10.1155/2008/359840 |
| Summary: | Melanoma associated-A antigens (MAGE-A) are silent in normal tissues except testis. However, they are activated in
a variety of different tumors. Thus, their expression is highly specific to cancer cells. Reverse transcription-nested polymerase
chain reaction (RT-nPCR) is a highly sensitive technique that has been used successfully for the detection ofMAGE genes in tissue
samples. The aim of the study is to analyze the expression rate of MAGE-A12 in oral squamous cell carcinoma (OSCC) using a
high sensitive RT-nPCR. Total of 57 tissue samples obtained from patients with OSCC and 20 normal oral mucosal (NOM) probes
of otherwise healthy volunteers were included to this study. No expression of MAGE-A12 was observed in the non-neoplastic
NOM tissues. MAGE-A12 was expressed in 49.1% of the investigated tumor samples. The correlation between malignant lesion
and MAGE-A12 detection was significant (p < 0.001). It is concluded that results of this study may indicate MAGE-A12 as
a useful additional diagnostic marker especially for the early detection of OSCC distinguishing neoplastic transformation and
detection of occult and/or rare disseminated cancer cells. In addition, MAGE-A12 expression in OSCC may also determine a
new immunotherapeutic target and might be warranted to develop vaccine for OSCC. |
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| ISSN: | 0278-0240 1875-8630 |