Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer
Resistance to therapy can be driven by intratumoral heterogeneity. Here, the authors show that drug tolerant persistent cell populations emerge during treatment, and these emergent populations arise through epigenetically mediated cell state transitions rather than sub population selection.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05729-w |
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doaj-b334216fc1b74e778b875f012ede0e202021-05-11T09:37:48ZengNature Publishing GroupNature Communications2041-17232018-09-019111710.1038/s41467-018-05729-wDifferentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancerTyler Risom0Ellen M. Langer1Margaret P. Chapman2Juha Rantala3Andrew J. Fields4Christopher Boniface5Mariano J. Alvarez6Nicholas D. Kendsersky7Carl R. Pelz8Katherine Johnson-Camacho9Lacey E. Dobrolecki10Koei Chin11Anil J. Aswani12Nicholas J. Wang13Andrea Califano14Michael T. Lewis15Claire J. Tomlin16Paul T. Spellman17Andrew Adey18Joe W. Gray19Rosalie C. Sears20Department of Molecular and Medical Genetics, Oregon Health & Science UniversityDepartment of Molecular and Medical Genetics, Oregon Health & Science UniversityDepartment of Electrical Engineering and Computer Sciences, University of California at BerkeleyMisvik BiologyDepartment of Molecular and Medical Genetics, Oregon Health & Science UniversityDepartment of Molecular and Medical Genetics, Oregon Health & Science UniversityDarwinHealth Inc.Department of Molecular and Medical Genetics, Oregon Health & Science UniversityDepartment of Molecular and Medical Genetics, Oregon Health & Science UniversityDepartment of Molecular and Medical Genetics, Oregon Health & Science UniversityLester and Sue Smith Breast Center, Baylor College of MedicineCenter for Spatial Systems Biomedicine, Oregon Health & Science UniversityDepartment of Industrial Engineering and Operations Research, University of California at BerkeleyCenter for Spatial Systems Biomedicine, Oregon Health & Science UniversityDarwinHealth Inc.Department of Biochemistry and Molecular Biology, Baylor College of MedicineDepartment of Electrical Engineering and Computer Sciences, University of California at BerkeleyDepartment of Molecular and Medical Genetics, Oregon Health & Science UniversityDepartment of Molecular and Medical Genetics, Oregon Health & Science UniversityCenter for Spatial Systems Biomedicine, Oregon Health & Science UniversityDepartment of Molecular and Medical Genetics, Oregon Health & Science UniversityResistance to therapy can be driven by intratumoral heterogeneity. Here, the authors show that drug tolerant persistent cell populations emerge during treatment, and these emergent populations arise through epigenetically mediated cell state transitions rather than sub population selection.https://doi.org/10.1038/s41467-018-05729-w |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Tyler Risom Ellen M. Langer Margaret P. Chapman Juha Rantala Andrew J. Fields Christopher Boniface Mariano J. Alvarez Nicholas D. Kendsersky Carl R. Pelz Katherine Johnson-Camacho Lacey E. Dobrolecki Koei Chin Anil J. Aswani Nicholas J. Wang Andrea Califano Michael T. Lewis Claire J. Tomlin Paul T. Spellman Andrew Adey Joe W. Gray Rosalie C. Sears |
| spellingShingle |
Tyler Risom Ellen M. Langer Margaret P. Chapman Juha Rantala Andrew J. Fields Christopher Boniface Mariano J. Alvarez Nicholas D. Kendsersky Carl R. Pelz Katherine Johnson-Camacho Lacey E. Dobrolecki Koei Chin Anil J. Aswani Nicholas J. Wang Andrea Califano Michael T. Lewis Claire J. Tomlin Paul T. Spellman Andrew Adey Joe W. Gray Rosalie C. Sears Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer Nature Communications |
| author_facet |
Tyler Risom Ellen M. Langer Margaret P. Chapman Juha Rantala Andrew J. Fields Christopher Boniface Mariano J. Alvarez Nicholas D. Kendsersky Carl R. Pelz Katherine Johnson-Camacho Lacey E. Dobrolecki Koei Chin Anil J. Aswani Nicholas J. Wang Andrea Califano Michael T. Lewis Claire J. Tomlin Paul T. Spellman Andrew Adey Joe W. Gray Rosalie C. Sears |
| author_sort |
Tyler Risom |
| title |
Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer |
| title_short |
Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer |
| title_full |
Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer |
| title_fullStr |
Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer |
| title_full_unstemmed |
Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer |
| title_sort |
differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-09-01 |
| description |
Resistance to therapy can be driven by intratumoral heterogeneity. Here, the authors show that drug tolerant persistent cell populations emerge during treatment, and these emergent populations arise through epigenetically mediated cell state transitions rather than sub population selection. |
| url |
https://doi.org/10.1038/s41467-018-05729-w |
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