Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide

Immune reconstitution inflammatory syndrome (IRIS) can complicate antifungal treatment of cryptococcosis. There are limited data on managing cryptococcal-associated IRIS. We describe an immunocompetent patient who developed IRIS complicating Cryptococcus neoformans meningitis, successfully treated...

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Main Authors:	Lucy K. Somerville, Andrew P. Henderson, Sharon C.A. Chen, Jen Kok
Format:	Article
Language:	English
Published:	Elsevier 2015-03-01
Series:	Medical Mycology Case Reports
Subjects:	Thalidomide Cryptococcus neoformans Immune reconstitution
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211753914000554

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spelling	doaj-b32e199e43a849a6883bf55039d1c1b92020-11-25T03:32:36ZengElsevierMedical Mycology Case Reports2211-75392015-03-017C121410.1016/j.mmcr.2014.12.003Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomideLucy K. Somerville0Andrew P. Henderson1Sharon C.A. Chen2Jen Kok3Centre for Infectious Diseases and Microbiology Laboratory Services, Level 3 Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales 2145, AustraliaDepartment of Neurology, Westmead Hospital, Westmead, New South Wales, AustraliaCentre for Infectious Diseases and Microbiology Laboratory Services, Level 3 Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales 2145, AustraliaCentre for Infectious Diseases and Microbiology Laboratory Services, Level 3 Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales 2145, Australia Immune reconstitution inflammatory syndrome (IRIS) can complicate antifungal treatment of cryptococcosis. There are limited data on managing cryptococcal-associated IRIS. We describe an immunocompetent patient who developed IRIS complicating Cryptococcus neoformans meningitis, successfully treated with thalidomide following failure of corticosteroid therapy. Data on thalidomide use in cryptococcal IRIS are awaited. http://www.sciencedirect.com/science/article/pii/S2211753914000554ThalidomideCryptococcus neoformansImmune reconstitution
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Lucy K. Somerville Andrew P. Henderson Sharon C.A. Chen Jen Kok
spellingShingle	Lucy K. Somerville Andrew P. Henderson Sharon C.A. Chen Jen Kok Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide Medical Mycology Case Reports Thalidomide Cryptococcus neoformans Immune reconstitution
author_facet	Lucy K. Somerville Andrew P. Henderson Sharon C.A. Chen Jen Kok
author_sort	Lucy K. Somerville
title	Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide
title_short	Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide
title_full	Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide
title_fullStr	Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide
title_full_unstemmed	Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide
title_sort	successful treatment of cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide
publisher	Elsevier
series	Medical Mycology Case Reports
issn	2211-7539
publishDate	2015-03-01
description	Immune reconstitution inflammatory syndrome (IRIS) can complicate antifungal treatment of cryptococcosis. There are limited data on managing cryptococcal-associated IRIS. We describe an immunocompetent patient who developed IRIS complicating Cryptococcus neoformans meningitis, successfully treated with thalidomide following failure of corticosteroid therapy. Data on thalidomide use in cryptococcal IRIS are awaited.
topic	Thalidomide Cryptococcus neoformans Immune reconstitution
url	http://www.sciencedirect.com/science/article/pii/S2211753914000554
work_keys_str_mv	AT lucyksomerville successfultreatmentofcryptococcusneoformansimmunereconstitutioninflammatorysyndromeinanimmunocompetenthostusingthalidomide AT andrewphenderson successfultreatmentofcryptococcusneoformansimmunereconstitutioninflammatorysyndromeinanimmunocompetenthostusingthalidomide AT sharoncachen successfultreatmentofcryptococcusneoformansimmunereconstitutioninflammatorysyndromeinanimmunocompetenthostusingthalidomide AT jenkok successfultreatmentofcryptococcusneoformansimmunereconstitutioninflammatorysyndromeinanimmunocompetenthostusingthalidomide
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Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide

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