Novel measure of lung function for assessing disease activity in asthma

IntroductionIn asthma, lung function measures are often discordant with clinical features such as disease activity or control.MethodsWe investigated a novel technique that provides a measure (σCL) of unevenness (inhomogeneity) in lung inflation/deflation. In particular, we compared σCL with FEV1% pr...

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Main Authors:	Nayia Petousi, Nick P Talbot, Ian Pavord, Peter A Robbins, Nicholas M J Smith, John Couper, Christopher J Fullerton, Graham Richmond, Gus Hancock, Grant A D Ritchie
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2020-05-01
Series:	BMJ Open Respiratory Research
Online Access:	https://bmjopenrespres.bmj.com/content/7/1/e000531.full

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spelling	doaj-b32ccc74944a4ff498ea812b739c607e2021-02-01T14:30:16ZengBMJ Publishing GroupBMJ Open Respiratory Research2052-44392020-05-017110.1136/bmjresp-2019-000531Novel measure of lung function for assessing disease activity in asthmaNayia PetousiNick P Talbot0Ian PavordPeter A RobbinsNicholas M J SmithJohn CouperChristopher J FullertonGraham RichmondGus HancockGrant A D Ritchieconsultant in respiratory medicineIntroductionIn asthma, lung function measures are often discordant with clinical features such as disease activity or control.MethodsWe investigated a novel technique that provides a measure (σCL) of unevenness (inhomogeneity) in lung inflation/deflation. In particular, we compared σCL with FEV1% predicted (FEV1%pred) as measures of disease activity in the asthmatic lung.ResultsσCL correlated modestly with FEV1%pred. However, σCL is not simply a proxy for FEV1%pred as the effects of salbutamol on the two parameters were unrelated. Importantly, σCL reflected disease control better than FEV1.DiscussionWe conclude that σCL shows promise as an objective measure of disease activity in asthma.https://bmjopenrespres.bmj.com/content/7/1/e000531.full
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nayia Petousi Nick P Talbot Ian Pavord Peter A Robbins Nicholas M J Smith John Couper Christopher J Fullerton Graham Richmond Gus Hancock Grant A D Ritchie
spellingShingle	Nayia Petousi Nick P Talbot Ian Pavord Peter A Robbins Nicholas M J Smith John Couper Christopher J Fullerton Graham Richmond Gus Hancock Grant A D Ritchie Novel measure of lung function for assessing disease activity in asthma BMJ Open Respiratory Research
author_facet	Nayia Petousi Nick P Talbot Ian Pavord Peter A Robbins Nicholas M J Smith John Couper Christopher J Fullerton Graham Richmond Gus Hancock Grant A D Ritchie
author_sort	Nayia Petousi
title	Novel measure of lung function for assessing disease activity in asthma
title_short	Novel measure of lung function for assessing disease activity in asthma
title_full	Novel measure of lung function for assessing disease activity in asthma
title_fullStr	Novel measure of lung function for assessing disease activity in asthma
title_full_unstemmed	Novel measure of lung function for assessing disease activity in asthma
title_sort	novel measure of lung function for assessing disease activity in asthma
publisher	BMJ Publishing Group
series	BMJ Open Respiratory Research
issn	2052-4439
publishDate	2020-05-01
description	IntroductionIn asthma, lung function measures are often discordant with clinical features such as disease activity or control.MethodsWe investigated a novel technique that provides a measure (σCL) of unevenness (inhomogeneity) in lung inflation/deflation. In particular, we compared σCL with FEV1% predicted (FEV1%pred) as measures of disease activity in the asthmatic lung.ResultsσCL correlated modestly with FEV1%pred. However, σCL is not simply a proxy for FEV1%pred as the effects of salbutamol on the two parameters were unrelated. Importantly, σCL reflected disease control better than FEV1.DiscussionWe conclude that σCL shows promise as an objective measure of disease activity in asthma.
url	https://bmjopenrespres.bmj.com/content/7/1/e000531.full
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Novel measure of lung function for assessing disease activity in asthma

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