Role of Interleukin 17 in Lung Carcinogenesis and Lung Cancer Progression

• Main Authors: Jiandong MEI, Lunxu LIU
• Format: Article
• Language: zho
• Published: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2016-01-01
• Series: Chinese Journal of Lung Cancer
• Subjects: Interleukin 17; Inflammation; Carcinogenesis; Cancer progression; Lung neoplasms
• Online Access: http://dx.doi.org/10.3779/j.issn.1009-3419.2016.01.06

Interleukin 17 (IL-17) is an important pro-inflammatory cytokine. It plays a critical role in mediating pathogen defense reactions, and the pathological inflammation of autoimmune diseases. IL-17 is also involved in various inflammation-related carcinogenesis. Cigarette smoking is one of the most important risk factors of lung cancer. Chronic inflammation caused by smoking and other factors is accompanied with overexpression of IL-17 within the airway, which reveals a potential relationship between IL-17 and lung carcinogenesis. Furthermore, IL-17 also plays a role in lung cancer progression via different mechanisms. In this paper, we summarized the results of current studies on IL-17 and lung carcinogenesis, as well as lung cancer progression.