Analysis and remedy of negativity problem in hybrid stochastic simulation algorithm and its application
Abstract Background The hybrid stochastic simulation algorithm, proposed by Haseltine and Rawlings (HR), is a combination of differential equations for traditional deterministic models and Gillespie’s algorithm (SSA) for stochastic models. The HR hybrid method can significantly improve the efficienc...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-06-01
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| Series: | BMC Bioinformatics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12859-019-2836-z |