Sleep impairment and reduced interneuron excitability in a mouse model of Dravet Syndrome

Sleep impairment and reduced interneuron excitability in a mouse model of Dravet Syndrome

Dravet Syndrome (DS) is caused by heterozygous loss-of-function mutations in voltage-gated sodium channel NaV1.1. Our mouse genetic model of DS recapitulates its severe seizures and premature death. Sleep disturbance is common in DS, but its mechanism is unknown. Electroencephalographic studies reve...

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Bibliographic Details
Main Authors: Franck Kalume, John C. Oakley, Ruth E. Westenbroek, Jennifer Gile, Horacio O. de la Iglesia, Todd Scheuer, William A. Catterall
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115000431

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