Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Streptococcal Skin Infection

Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Streptococcal Skin Infection

The bacterial pathogen Group A Streptococcus (GAS) has been shown to induce a variety of human diseases ranging in severity from pharyngitis to toxic shock syndrome and necrotizing fasciitis. GAS produces a powerful peptide toxin known as Streptolysin S (SLS). Though long recognized as a potent cyto...

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Bibliographic Details
Main Authors: Rebecca A. Flaherty, Deborah L. Donahue, Katelyn E. Carothers, Jessica N. Ross, Victoria A. Ploplis, Francis J. Castellino, Shaun W. Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Streptolysin S
host-pathogen interactions
inflammatory signaling
p38 MAPK
cytokine
interleukin-1 beta
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00211/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2018.00211/full

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