Targeting mTOR for cancer therapy

Targeting mTOR for cancer therapy

Abstract Mechanistic target of rapamycin (mTOR) is a protein kinase regulating cell growth, survival, metabolism, and immunity. mTOR is usually assembled into several complexes such as mTOR complex 1/2 (mTORC1/2). In cooperation with raptor, rictor, LST8, and mSin1, key components in mTORC1 or mTORC...

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Bibliographic Details
Main Authors: Hui Hua, Qingbin Kong, Hongying Zhang, Jiao Wang, Ting Luo, Yangfu Jiang
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Hematology & Oncology
Subjects:
Cancer
Drug resistance
mTOR
Oncogene
Targeted therapy
Online Access:http://link.springer.com/article/10.1186/s13045-019-0754-1

Internet

http://link.springer.com/article/10.1186/s13045-019-0754-1

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