Bleeding is increased in amyloid precursor protein knockout mouse

Bleeding is increased in amyloid precursor protein knockout mouse

Abstract Background Amyloid precursor protein (APP) is highly expressed in platelets. APP is the precursor to amyloid beta (Aβ) peptides that accumulate in cerebral amyloid angiopathy and plaques in Alzheimer disease. APP and its metabolites interact with many components of the coagulation system, a...

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Bibliographic Details
Main Authors: Nima Mazinani, Amy W. Strilchuk, James R. Baylis, Woosuk S. Hur, Wilfred A. Jefferies, Christian J. Kastrup
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
blood coagulation
cerebral amyloid angiopathy
fibrinolysis
hemorrhage
neurodegenerative diseases
thrombosis
Online Access:https://doi.org/10.1002/rth2.12375

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