Vagotomy Affects the Development of Oral Tolerance and Increases Susceptibility to Develop Colitis Independently of α-7 Nicotinic Receptor

Vagotomy Affects the Development of Oral Tolerance and Increases Susceptibility to Develop Colitis Independently of α-7 Nicotinic Receptor

Abstract Vagotomy (VGX) increases the susceptibility to develop colitis suggesting a crucial role for the cholinergic anti-inflammatory pathway in the regulation of the immune responses. Since oral tolerance and the generation of regulatory T cells (Tregs) are crucial to preserve mucosal immune home...

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Bibliographic Details
Main Authors: Martina Di Giovangiulio, Goele Bosmans, Elisa Meroni, Nathalie Stakenborg, Morgane Florens, Giovanna Farro, Pedro J Gomez-Pinilla, Gianluca Matteoli, Guy E Boeckxstaens
Format: Article
Language:English
Published: BMC 2016-06-01
Series:Molecular Medicine
Online Access:http://link.springer.com/article/10.2119/molmed.2016.00062

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http://link.springer.com/article/10.2119/molmed.2016.00062

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