Combined chronic blockade of hyper-active L-type calcium channels and NMDA receptors ameliorates HIV-1 associated hyper-excitability of mPFC pyramidal neurons

Combined chronic blockade of hyper-active L-type calcium channels and NMDA receptors ameliorates HIV-1 associated hyper-excitability of mPFC pyramidal neurons

Human Immunodeficiency Virus type 1 (HIV-1) infection induces neurological and neuropsychological deficits, which are associated with dysregulation of the medial prefrontal cortex (mPFC) and other vulnerable brain regions. We evaluated the impact of HIV infection in the mPFC and the therapeutic pote...

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Bibliographic Details
Main Authors: Christina E. Khodr, Lihua Chen, Sonya Dave, Lena Al-Harthi, Xiu-Ti Hu
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Neurobiology of Disease
Subjects:
HIV
Medial prefrontal cortex
Calcium
L-channel
NMDAR
Pyramidal neuron
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116301413

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