Humanized-VHH Transbodies that Inhibit HCV Protease and Replication

Humanized-VHH Transbodies that Inhibit HCV Protease and Replication

There is a need for safe and broadly effective anti-HCV agents that can cope with genetic multiplicity and mutations of the virus. In this study, humanized-camel VHHs to genotype 3a HCV serine protease were produced and were linked molecularly to a cell penetrating peptide, penetratin (PEN). Human h...

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Bibliographic Details
Main Authors: Surasak Jittavisutthikul, Jeeraphong Thanongsaksrikul, Kanyarat Thueng-in, Monrat Chulanetra, Potjanee Srimanote, Watee Seesuay, Aijaz Ahmad Malik, Wanpen Chaicumpa
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Viruses
Subjects:
Anti-hepatitis C virus (HCV) agent
HCV protease
homology modeling and molecular docking
nanobody
VHH
phage display
transbody
Online Access:http://www.mdpi.com/1999-4915/7/4/2030

Internet

http://www.mdpi.com/1999-4915/7/4/2030

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