Quercetin promotes antipromastigote effect by increasing the ROS production and anti-amastigote by upregulating Nrf2/HO-1 expression, affecting iron availability

Quercetin promotes antipromastigote effect by increasing the ROS production and anti-amastigote by upregulating Nrf2/HO-1 expression, affecting iron availability

American cutaneous leishmaniasis is a zoonotic disease caused by protozoans of the genus Leishmania. The treatment of cutaneous leishmaniasis is unsatisfactory, thus, much research effort has been focused on investigating new compounds with lower collateral effects to the patients and derived from l...

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Bibliographic Details
Main Authors: Allan Henrique Depieri Cataneo, Fernanda Tomiotto-Pellissier, Milena Menegazzo Miranda-Sapla, João Paulo Assolini, Carolina Panis, Danielle Kian, Lucy Megumi Yamauchi, Andrea Name Colado Simão, Rubia Casagrande, Phileno Pinge-Filho, Idessania Nazareth Costa, Waldiceu Ap. Verri, Jr., Ivete Conchon-Costa, Wander Rogério Pavanelli
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Leishmaniasis
Macrophages
Cytokines
Flavonoid
Antioxidant
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218365181

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