Structural Diversity of Ultralong CDRH3s in Seven Bovine Antibody Heavy Chains

Structural Diversity of Ultralong CDRH3s in Seven Bovine Antibody Heavy Chains

Antigen recognition by mammalian antibodies represents the most diverse setting for protein-protein interactions, because antibody variable regions contain exceptionally diverse variable gene repertoires of DNA sequences containing combinatorial, non-templated junctional mutational diversity. Some a...

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Bibliographic Details
Main Authors: Jinhui Dong, Jessica A. Finn, Peter A. Larsen, Timothy P. L. Smith, James E. Crowe
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
lymphocytes
monoclonal antibody
antigen-antibody recognition
Bos taurus
ultralong CDRH3
crystal structure
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00558/full

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