Nanoscale Organisation of Ryanodine Receptors and Junctophilin-2 in the Failing Human Heart

Nanoscale Organisation of Ryanodine Receptors and Junctophilin-2 in the Failing Human Heart

The disrupted organisation of the ryanodine receptors (RyR) and junctophilin (JPH) is thought to underpin the transverse tubule (t-tubule) remodelling in a failing heart. Here, we assessed the nanoscale organisation of these two key proteins in the failing human heart. Recently, an advanced feature...

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Bibliographic Details
Main Authors: Yufeng Hou, Jizhong Bai, Xin Shen, Oscar de Langen, Amy Li, Sean Lal, Cristobal G. dos Remedios, David Baddeley, Peter N. Ruygrok, Christian Soeller, David J. Crossman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Physiology
Subjects:
t-tubules
ryanodine receptor
collagen VI
fibrosis
junctophilin
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.724372/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.724372/full

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