New Di-(β-chloroethyl)-α-amides on N-(meta-Acylaminobenzoyl)- D,L-aminoacid Supports with Antitumoral Activity

New Di-(β-chloroethyl)-α-amides on N-(meta-Acylaminobenzoyl)- D,L-aminoacid Supports with Antitumoral Activity

In order to obtain new compounds with antitumoural action the N-(metaacylaminobenzoyl)-α-acylaminobenzoyl)-α-aminoacids 4-9 were prepared. Thesecompounds were subsequently converted into the corresponding δ2-oxazolin-5-ones 10-15,which in turn were submitted to a ring opening reaction with...

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Bibliographic Details
Main Authors: Lionte Catalina, Pintilie Otilia, Lenuta Profire, Jacques Desbrières, Marcel Popa, Valeriu Sunel
Format: Article
Language:English
Published: MDPI AG 2008-01-01
Series:Molecules
Subjects:
N-(acylaminobenzoyl)-α-aminoacids
Δ2-oxazolin-5-ones
anticancer agents
Online Access:http://www.mdpi.com/1420-3049/13/1/177/
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spelling doaj-b2bb85ba409246fdb48a697707f844e22020-11-24T20:59:23ZengMDPI AGMolecules1420-30492008-01-0113117718910.3390/molecules13010177New Di-(β-chloroethyl)-α-amides on N-(meta-Acylaminobenzoyl)- D,L-aminoacid Supports with Antitumoral ActivityLionte CatalinaPintilie OtiliaLenuta ProfireJacques DesbrièresMarcel PopaValeriu SunelIn order to obtain new compounds with antitumoural action the N-(metaacylaminobenzoyl)-α-acylaminobenzoyl)-α-aminoacids 4-9 were prepared. Thesecompounds were subsequently converted into the corresponding δ2-oxazolin-5-ones 10-15,which in turn were submitted to a ring opening reaction with di-(β-chloroethyl)amine toafford the peptide supported N-mustards 16-21, which showed low toxicity and cytostaticactivity similar to that of sarcolisine against the Ehrlich ascite and Walker 253carcinosarcoma.http://www.mdpi.com/1420-3049/13/1/177/N-(acylaminobenzoyl)-α-aminoacidsΔ2-oxazolin-5-onesanticancer agents
collection DOAJ
language English
format Article
sources DOAJ
author Lionte Catalina
Pintilie Otilia
Lenuta Profire
Jacques Desbrières
Marcel Popa
Valeriu Sunel
spellingShingle Lionte Catalina
Pintilie Otilia
Lenuta Profire
Jacques Desbrières
Marcel Popa
Valeriu Sunel
New Di-(β-chloroethyl)-α-amides on N-(meta-Acylaminobenzoyl)- D,L-aminoacid Supports with Antitumoral Activity
Molecules
N-(acylaminobenzoyl)-α-aminoacids
Δ2-oxazolin-5-ones
anticancer agents
author_facet Lionte Catalina
Pintilie Otilia
Lenuta Profire
Jacques Desbrières
Marcel Popa
Valeriu Sunel
author_sort Lionte Catalina
title New Di-(β-chloroethyl)-α-amides on N-(meta-Acylaminobenzoyl)- D,L-aminoacid Supports with Antitumoral Activity
title_short New Di-(β-chloroethyl)-α-amides on N-(meta-Acylaminobenzoyl)- D,L-aminoacid Supports with Antitumoral Activity
title_full New Di-(β-chloroethyl)-α-amides on N-(meta-Acylaminobenzoyl)- D,L-aminoacid Supports with Antitumoral Activity
title_fullStr New Di-(β-chloroethyl)-α-amides on N-(meta-Acylaminobenzoyl)- D,L-aminoacid Supports with Antitumoral Activity
title_full_unstemmed New Di-(β-chloroethyl)-α-amides on N-(meta-Acylaminobenzoyl)- D,L-aminoacid Supports with Antitumoral Activity
title_sort new di-(ãžâ²-chloroethyl)-ãžâ±-amides on n-(meta-acylaminobenzoyl)- d,l-aminoacid supports with antitumoral activity
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2008-01-01
description In order to obtain new compounds with antitumoural action the N-(metaacylaminobenzoyl)-α-acylaminobenzoyl)-α-aminoacids 4-9 were prepared. Thesecompounds were subsequently converted into the corresponding δ2-oxazolin-5-ones 10-15,which in turn were submitted to a ring opening reaction with di-(β-chloroethyl)amine toafford the peptide supported N-mustards 16-21, which showed low toxicity and cytostaticactivity similar to that of sarcolisine against the Ehrlich ascite and Walker 253carcinosarcoma.
topic N-(acylaminobenzoyl)-α-aminoacids
Δ2-oxazolin-5-ones
anticancer agents
url http://www.mdpi.com/1420-3049/13/1/177/
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AT pintilieotilia newdiaza2chloroethylazaamidesonnmetaacylaminobenzoyldlaminoacidsupportswithantitumoralactivity
AT lenutaprofire newdiaza2chloroethylazaamidesonnmetaacylaminobenzoyldlaminoacidsupportswithantitumoralactivity
AT jacquesdesbriaƒares newdiaza2chloroethylazaamidesonnmetaacylaminobenzoyldlaminoacidsupportswithantitumoralactivity
AT marcelpopa newdiaza2chloroethylazaamidesonnmetaacylaminobenzoyldlaminoacidsupportswithantitumoralactivity
AT valeriusunel newdiaza2chloroethylazaamidesonnmetaacylaminobenzoyldlaminoacidsupportswithantitumoralactivity
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