Hyaluronic acid-coated nanoemulsions loaded with a hydrophobic ion pair of all-trans retinoic acid for improving the anticancer activity

Hyaluronic acid-coated nanoemulsions loaded with a hydrophobic ion pair of all-trans retinoic acid for improving the anticancer activity

All-trans retinoic acid (ATRA) has been studied for the treatment of cancer, including leukemia and breast cancer. This work aims to develop nanoemulsions (NE) loaded with a hydrophobic ion pair (HIP) of all-trans retinoic acid (ATRA) and a lipophilic amine, stearylamine (SA), and coated with hyalur...

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Bibliographic Details
Main Authors: Letícia Márcia da Silva Tinoco, Flávia Lidiane Oliveira da Silva, Lucas Antônio Miranda Ferreira, Elaine Amaral Leite, Guilherme Carneiro
Format: Article
Language:English
Published: Universidade de São Paulo 2019-04-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
All-trans-retinoic acid
Breast neoplasms.Drug delivery
Hyaluronic acid
Nanoemulsion
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400616&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400616&lng=en&tlng=en

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