S1P1 localizes to the colonic vasculature in ulcerative colitis and maintains blood vessel integrity

S1P1 localizes to the colonic vasculature in ulcerative colitis and maintains blood vessel integrity

Signaling through sphingosine-1-phosphate receptor1 (S1P1) promotes blood vessel barrier function. Degradation of S1P1 results in increased vascular permeability in the lung and may explain side effects associated with administration of FTY720, a functional antagonist of the S1P1 receptor that is cu...

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Bibliographic Details
Main Authors: David C. Montrose, Ellen J. Scherl, Brian P. Bosworth, Xi Kathy Zhou, Bongnam Jung, Andrew J. Dannenberg, Timothy Hla
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Journal of Lipid Research
Subjects:
inflammatory bowel disease
Fingolimod
endothelial cells
sphingosine-1-phosphate
gastrointestinal bleeding
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520419480

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