Bioadhesive Surfactant Systems for Methotrexate Skin Delivery

Bioadhesive Surfactant Systems for Methotrexate Skin Delivery

Methotrexate (MTX) is an immunosuppressive drug for systemic use in the treatment of skin diseases, however, MTX presents a number of side effects, such as hepatotoxicity. To overcome this limitation, this study developed skin MTX delivery surfactant systems, such as a microemulsion (ME) and a liqui...

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Bibliographic Details
Main Authors: Giovana Aparecida de Souza Cintra, Larissa Alvarenga Pinto, Giovana Maria Fioramonti Calixto, Christiane Pienna Soares, Eliete de Souza Von Zuben, Maria Virgínia Scarpa, Maria Palmira Daflon Gremião, Marlus Chorilli
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:Molecules
Subjects:
microemulsion
liquid-crystalline systems
in vitro skin permeation
in vitro skin retention
polyether functional siloxane
methotrexate
Online Access:http://www.mdpi.com/1420-3049/21/2/231

Internet

http://www.mdpi.com/1420-3049/21/2/231

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