A molecular portrait of microsatellite instability across multiple cancers

A molecular portrait of microsatellite instability across multiple cancers

Some cancers with DNA mismatch repair deficiency display microsatellite instability. Here the authors analyse twenty three cancer types at the exome and whole-genome level, and identify loci with recurrent microsatellite instability that could be used to identify patients who would benefit from immu...

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Main Authors: Isidro Cortes-Ciriano, Sejoon Lee, Woong-Yang Park, Tae-Min Kim, Peter J. Park
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15180
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spelling doaj-b2b03e49a2a0482ab2a3e3eccf1875e92021-05-11T07:21:45ZengNature Publishing GroupNature Communications2041-17232017-06-018111210.1038/ncomms15180A molecular portrait of microsatellite instability across multiple cancersIsidro Cortes-Ciriano0Sejoon Lee1Woong-Yang Park2Tae-Min Kim3Peter J. Park4Department of Biomedical Informatics, Harvard Medical SchoolSamsung Genome Institute, Samsung Medical CenterSamsung Genome Institute, Samsung Medical CenterDepartment of Medical Informatics and Catholic Cancer Research Institute, College of Medicine, The Catholic University of KoreaDepartment of Biomedical Informatics, Harvard Medical SchoolSome cancers with DNA mismatch repair deficiency display microsatellite instability. Here the authors analyse twenty three cancer types at the exome and whole-genome level, and identify loci with recurrent microsatellite instability that could be used to identify patients who would benefit from immunotherapy.https://doi.org/10.1038/ncomms15180
collection DOAJ
language English
format Article
sources DOAJ
author Isidro Cortes-Ciriano
Sejoon Lee
Woong-Yang Park
Tae-Min Kim
Peter J. Park
spellingShingle Isidro Cortes-Ciriano
Sejoon Lee
Woong-Yang Park
Tae-Min Kim
Peter J. Park
A molecular portrait of microsatellite instability across multiple cancers
Nature Communications
author_facet Isidro Cortes-Ciriano
Sejoon Lee
Woong-Yang Park
Tae-Min Kim
Peter J. Park
author_sort Isidro Cortes-Ciriano
title A molecular portrait of microsatellite instability across multiple cancers
title_short A molecular portrait of microsatellite instability across multiple cancers
title_full A molecular portrait of microsatellite instability across multiple cancers
title_fullStr A molecular portrait of microsatellite instability across multiple cancers
title_full_unstemmed A molecular portrait of microsatellite instability across multiple cancers
title_sort molecular portrait of microsatellite instability across multiple cancers
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-06-01
description Some cancers with DNA mismatch repair deficiency display microsatellite instability. Here the authors analyse twenty three cancer types at the exome and whole-genome level, and identify loci with recurrent microsatellite instability that could be used to identify patients who would benefit from immunotherapy.
url https://doi.org/10.1038/ncomms15180
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AT sejoonlee molecularportraitofmicrosatelliteinstabilityacrossmultiplecancers
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AT taeminkim molecularportraitofmicrosatelliteinstabilityacrossmultiplecancers
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