Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role

Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role

<p>Abstract</p> <p>Background</p> <p>Regulated intramembrane proteolysis of the β-amyloid precursor protein by the γ-secretase yields two peptides. One, amyloid-β, is the major component of the amyloid plaques found in Alzheimer's disease patients. The other, APP I...

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Bibliographic Details
Main Authors: De Luca Pasquale, Tamagno Elena, Weldon Richard, Zhou Dawang, Giliberto Luca, Tabaton Massimo, D'Adamio Luciano
Format: Article
Language:English
Published: BMC 2008-09-01
Series:Molecular Neurodegeneration
Online Access:http://www.molecularneurodegeneration.com/content/3/1/12

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