The pulsed ultrasound strategy effectively decreases the S. aureus population of chronic rhinosinusitis patients

• Main Authors: Narjes Feizabadi, Javad Sarrafzadeh, Mojtaba Fathali, Behnoosh Vasaghi-Gharamaleki, Mahdi Dadgoo, Jalil Kardan-Yamchi, Hossein Kazemian, Sonia Hesam-Shariati, Mohammad Mehdi Feizabadi
• Format: Article
• Language: English
• Published: BMC 2019-09-01
• Series: BMC Research Notes
• Subjects: Pulsed ultrasound; Chronic rhinosinusitis; Staphylococcus aureus; Treatment; Real-time PCR
• Online Access: http://link.springer.com/article/10.1186/s13104-019-4579-3
• ISSN: 1756-0500

Abstract Objective Staphylococcus aureus with the ability of biofilm formation and the drug resistance acquisition is one of the most frequently isolated pathogens from chronic rhinosinusitis patients. Ultrasound as an alternative therapy is effectively able to kill the bacteria by cavitation in or on the bacterial cells and peroxide generation and hence improving antibiotic treatment efficacy. Results Staphylococcus aureus was detected in 4 and 6 out of 14 patients by phenotypic and qPCR assays, respectively. Four patients were completely resolved after pulsed ultrasound treatment. However, presence of the S. aureus was confirmed in three healthy controls by bacterial cultivation. Pulsed ultrasound have been quantitatively decreased the S. aureus population in chronic rhinosinusitis patients (p < 0.05). Further studies need to be investigated the effectiveness of pulsed ultrasound as an alternative course of CRS patient’s treatment.