Ixeris sonchifolia: a review of its traditional uses, chemical constituents, pharmacology and modern applications

• Main Authors: Kun-Wei Li, Yi-Yu Liang, Shi-Min Xie, Feng-Jv Niu, Ling-Yan Guo, Zi-Hao Liu, Chang-Zheng Zhou, Li-Zhu Wang
• Format: Article
• Language: English
• Published: Elsevier 2020-05-01
• Series: Biomedicine & Pharmacotherapy
• Subjects: Ixeris sonchifolia(IS); Traditional uses; Chemical constituents; Quality control; Pharmacological activities; Clinical studies
• Online Access: http://www.sciencedirect.com/science/article/pii/S0753332220300597

Ixeris sonchifolia (IS), principally its dried form, is widely used as traditional and folk medicines in some Asian countries, especially China. In this review, we summarized its traditional uses, chemical constituents, quality control measures, pharmacological activities, therapeutic evaluation, toxicity evaluation and clinical applications. 130 chemical constituents isolated from IS have been reported, including flavones, sesquiterpenes, triterpenes, phenylpropanoids, organic acids and others. They showed various pharmacological activities, such as protecting cardiocerebral vascular system, anticancer effect and antiviral etc. The quality control evaluation studies, clinical applications, other possible applications and suggestions for future research also were discussed. The aim of this review is to critically appraise the available literature and suggest directions for further development of IS to improve its medical value and use.