Clinical and laboratory substantiation of Mexidol use in complex treatment of periodontitis in patients with peptic ulcers

• Main Authors: Ostrovskaya L.U., Kobzeva U.A., Kharish N.A.
• Format: Article
• Language: Russian
• Published: Saratov State Medical University 2011-06-01
• Series: Саратовский научно-медицинский журнал
• Subjects: mexidol; peptic ulcer; periodontitis
• Online Access: http://www.ssmj.ru/system/files/201102_481-485.pdf

To determine the clinical pathogenetic efficacy of Mexidol in the combined therapy of parodontitis in patients with peptic ulcers medical examination and treatment of 296 patients were carried out. Endoscopic, histological and im-munohistochemical studies were performed in all examined patients. Investigation of interleukin -6, -10, -18 in oral cavity by immunofermental analysis was conducted. It was established that Mexidol use in the combined treatment of patients with periodontitis and peptic ulcer allowed to decrease evidence of local inflammation, to normalize processes of neurohumoral and cytokine regulation, that provided acceleration of recovery processes, decrease in periodontitis recurrences. The statistical programs Exsel и Statistica 6.0 were used in the study. The subsequent analysis of the received data was carried out