Developmental Changes in HCN Channel Modulation of Neocortical Layer 1 Interneurons

Developmental Changes in HCN Channel Modulation of Neocortical Layer 1 Interneurons

Layer 1 (L1) interneurons (INs) play a key role in modulating the integration of inputs to pyramidal neurons (PNs) and controlling cortical network activity. Hyperpolarization-activated, cyclic nucleotide-gated, non-specific cation (HCN) channels are known to alter the intrinsic and synaptic excitab...

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Bibliographic Details
Main Authors: Andrew S. Bohannon, John J. Hablitz
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
HCN channels
interneuron development
layer 1
medial agranular cortex
synaptic integration
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00020/full

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