DURABLE RESPONSE OF SPINAL CHORDOMA TO COMBINED INHIBITION OF IGF-1R AND EGFR

DURABLE RESPONSE OF SPINAL CHORDOMA TO COMBINED INHIBITION OF IGF-1R AND EGFR

Chordomas are rare primary malignant bone tumors arising from embryonal notochord remnants of the axial skeleton. Chordomas commonly recur following surgery and radiotherapy, and there is no effective systemic therapy. Previous studies implicated receptor tyrosine kinases including epidermal growth...

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Bibliographic Details
Main Authors: Tamara eAleksic, Lisa eBrowning, Martha eWoodward, Rachel ePhillips, Suzanne ePage, Shirley eHenderson, Nicholas eAthanasou, Olaf eAnsorge, Duncan eWhitwell, Sarah ePratap, Andrew Bassim Hassan, Mark eMiddleton, Valentine Moya Macaulay
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Oncology
Subjects:
Chordoma
EGFR
IGF-1R
tyrosine kinase inhibitor
nuclear IGF-1R
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00098/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00098/full

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