THE COMPLEX OF INFORMATIVE IMMUNOLOGICAL PARAMETERS FOR BREAST CANCER OUTCOME PROGNOSIS

• Main Authors: M. N. Stakheyeva, A. P. Serykh, S. I. Karas, E. A. Perina
• Format: Article
• Language: English
• Published: Siberian State Medical University (Tomsk) 2015-06-01
• Series: Bûlleten' Sibirskoj Mediciny
• Subjects: prognosis criteria; breast cancer; immune system; information value
• Online Access: https://bulletin.tomsk.ru/jour/article/view/168

Prognosis of disease outcome is important procedure for cancer patients treatment. The article presents the problem of elicitation of breast cancer prognosis criteria from immunological data as parameters complex.The aim is to identify necessary and sufficient amount of immunological parameters for accurate classification of breast cancer patients with various outcomes – clinical remission and hematogenous metastases.Material and methods. 36 immunological parameters were studied in 197 breast cancer patients T1–4N0–3M0. The “next neighbor” algorithm was used for identification of informative parameters. Detection of informative parameters complex was carried out by using ADD and DEL methods.Results. Two sets of informative immunological parameters were detected. The ADD method elicited parameters related to T-cell immunity, DEL – to humoral response.Conclusions. The complex of 17–19 immunological parameters characterizing different elements of immune system is necessary for accurate classification of breast cancer patients with different outcomes (presence/absence of hematogenous metastases).