An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques
A vaccine protecting from SARS-CoV-2 infection is needed. Here the authors generate a replication-incompetent adenovirus based vaccine expressing SARS-CoV-2 spike, show protection from infection in non-human primates, and analyze the immune response after intramuscular and intranasal vaccination.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18077-5 |
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doaj-b2722cb9b68f42f095aa1611002a534b |
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| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Liqiang Feng Qian Wang Chao Shan Chenchen Yang Ying Feng Jia Wu Xiaolin Liu Yiwu Zhou Rendi Jiang Peiyu Hu Xinglong Liu Fan Zhang Pingchao Li Xuefeng Niu Yichu Liu Xuehua Zheng Jia Luo Jing Sun Yingying Gu Bo Liu Yongcun Xu Chufang Li Weiqi Pan Jincun Zhao Changwen Ke Xinwen Chen Tao Xu Nanshan Zhong Suhua Guan Zhiming Yuan Ling Chen |
| spellingShingle |
Liqiang Feng Qian Wang Chao Shan Chenchen Yang Ying Feng Jia Wu Xiaolin Liu Yiwu Zhou Rendi Jiang Peiyu Hu Xinglong Liu Fan Zhang Pingchao Li Xuefeng Niu Yichu Liu Xuehua Zheng Jia Luo Jing Sun Yingying Gu Bo Liu Yongcun Xu Chufang Li Weiqi Pan Jincun Zhao Changwen Ke Xinwen Chen Tao Xu Nanshan Zhong Suhua Guan Zhiming Yuan Ling Chen An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques Nature Communications |
| author_facet |
Liqiang Feng Qian Wang Chao Shan Chenchen Yang Ying Feng Jia Wu Xiaolin Liu Yiwu Zhou Rendi Jiang Peiyu Hu Xinglong Liu Fan Zhang Pingchao Li Xuefeng Niu Yichu Liu Xuehua Zheng Jia Luo Jing Sun Yingying Gu Bo Liu Yongcun Xu Chufang Li Weiqi Pan Jincun Zhao Changwen Ke Xinwen Chen Tao Xu Nanshan Zhong Suhua Guan Zhiming Yuan Ling Chen |
| author_sort |
Liqiang Feng |
| title |
An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques |
| title_short |
An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques |
| title_full |
An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques |
| title_fullStr |
An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques |
| title_full_unstemmed |
An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques |
| title_sort |
adenovirus-vectored covid-19 vaccine confers protection from sars-cov-2 challenge in rhesus macaques |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-08-01 |
| description |
A vaccine protecting from SARS-CoV-2 infection is needed. Here the authors generate a replication-incompetent adenovirus based vaccine expressing SARS-CoV-2 spike, show protection from infection in non-human primates, and analyze the immune response after intramuscular and intranasal vaccination. |
| url |
https://doi.org/10.1038/s41467-020-18077-5 |
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doaj-b2722cb9b68f42f095aa1611002a534b2021-08-22T11:40:55ZengNature Publishing GroupNature Communications2041-17232020-08-0111111110.1038/s41467-020-18077-5An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaquesLiqiang Feng0Qian Wang1Chao Shan2Chenchen Yang3Ying Feng4Jia Wu5Xiaolin Liu6Yiwu Zhou7Rendi Jiang8Peiyu Hu9Xinglong Liu10Fan Zhang11Pingchao Li12Xuefeng Niu13Yichu Liu14Xuehua Zheng15Jia Luo16Jing Sun17Yingying Gu18Bo Liu19Yongcun Xu20Chufang Li21Weiqi Pan22Jincun Zhao23Changwen Ke24Xinwen Chen25Tao Xu26Nanshan Zhong27Suhua Guan28Zhiming Yuan29Ling Chen30Bioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesBioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesState Key Laboratory of Virology, Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of SciencesGuangzhou nBiomed LtdState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Virology, Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of SciencesGuangzhou nBiomed LtdDepartment of Forensic Medicine, Tongji Medical College of Huazhong University of Science and TechnologyState Key Laboratory of Virology, Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of SciencesBioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesBioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesBioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesBioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityBioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesBioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesBioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou nBiomed LtdGuangzhou nBiomed LtdState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityGuangdong Provincial Center for Disease Control and PreventionBioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesBioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou nBiomed LtdState Key Laboratory of Virology, Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of SciencesBioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesA vaccine protecting from SARS-CoV-2 infection is needed. Here the authors generate a replication-incompetent adenovirus based vaccine expressing SARS-CoV-2 spike, show protection from infection in non-human primates, and analyze the immune response after intramuscular and intranasal vaccination.https://doi.org/10.1038/s41467-020-18077-5 |