Management of a case of Candida albicans endogenous endophthalmitis with intravitreal caspofungin

• Main Authors: Harshali Manish Yadav, Boben Thomas, Cherian Thampy, Tandava Krishnan Panaknti
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2017-01-01
• Series: Indian Journal of Ophthalmology
• Subjects: Candida albicans; caspofungin; endogenous endophthalmitis; intravitreal injections
• Online Access: http://www.ijo.in/article.asp?issn=0301-4738;year=2017;volume=65;issue=6;spage=529;epage=531;aulast=Yadav
• ISSN: 0301-4738; 1998-3689

We report a case of Candida albicans endogenous endophthalmitis treated with intravitreal caspofungin. The patient was a known case of acute lymphoblastic leukemia on chemotherapy and presented to us with features suggestive of endogenous endophthalmitis. He was treated initially with intravenous (IV) caspofungin and intravitreal amphotericin B. Patients condition worsened after IV caspofungin was replaced by amphotericin B necessitating a core vitrectomy. The patient was given the option of off-label caspofungin intravitreal injection for which the patient consented. There was a gradual improvement in the clinical picture. The situation worsened after the injections were stopped necessitating a revitrectomy. The study demonstrates the clinical efficacy of intravitreal caspofungin for the first time in human eyes.