Toluidine blue O and porphyrin-mediated photodynamic therapy on three main pathogenic bacteria of periodontitis using portable LED phototherapy device

Toluidine blue O and porphyrin-mediated photodynamic therapy on three main pathogenic bacteria of periodontitis using portable LED phototherapy device

Photodynamic therapy (PDT) has been commonly used in treating many diseases, such as cancer and infectious diseases. We investigated the different effects of PDT on three main pathogenic bacteria of periodontitis — Prevotella melaninogenica (P.m.), Porphyromonas gingivalis (P.g.) and Aggregatibacter...

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Main Authors: Xuewei Jiang, Zhichao Fan, Yili Yu, Chenying Shao, Yuanzhen Suo, Xunbin Wei, Yi Zhou
Format: Article
Language:English
Published: World Scientific Publishing 2015-07-01
Series:Journal of Innovative Optical Health Sciences
Subjects:
Photodynamic therapy
periodontitis
toluidine blue O
endogenous photosensitizer
survival rate
Online Access:http://www.worldscientific.com/doi/pdf/10.1142/S1793545815500170
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spelling doaj-b26bb9580e6247c59f4ab175a52357342020-11-24T23:39:53ZengWorld Scientific PublishingJournal of Innovative Optical Health Sciences1793-54581793-72052015-07-01841550017-11550017-710.1142/S179354581550017010.1142/S1793545815500170Toluidine blue O and porphyrin-mediated photodynamic therapy on three main pathogenic bacteria of periodontitis using portable LED phototherapy deviceXuewei Jiang0Zhichao Fan1Yili Yu2Chenying Shao3Yuanzhen Suo4Xunbin Wei5Yi Zhou6Department of Stomatology, Huashan Hospital, Fudan University, Shanghai, P. R. ChinaInstitutes of Biomedical Sciences, Fudan University, Shanghai, P. R. ChinaDepartment of Stomatology, Huashan Hospital, Fudan University, Shanghai, P. R. ChinaDepartment of Stomatology, Huashan Hospital, Fudan University, Shanghai, P. R. ChinaMed-X Research Institute, Shanghai Jiao Tong University, Shanghai, P. R. ChinaInstitutes of Biomedical Sciences, Fudan University, Shanghai, P. R. ChinaDepartment of Stomatology, Huashan Hospital, Fudan University, Shanghai, P. R. ChinaPhotodynamic therapy (PDT) has been commonly used in treating many diseases, such as cancer and infectious diseases. We investigated the different effects of PDT on three main pathogenic bacteria of periodontitis — Prevotella melaninogenica (P.m.), Porphyromonas gingivalis (P.g.) and Aggregatibacter actinomycetemcomitans (A.a.). The portable red light-emitting diode (LED) phototherapy device was used to assess the exogenous PDT effects with different light doses and photosensitizer concentrations (Toluidine blue O, TBO). The portable blue LED phototherapy device was used to assess the endogenous PDT effects with the use of endogenous photosensitizers (porphyrin) under different light doses. We found out that both exogenous and endogenous PDT were able to restrict the growth of all the three bacteria significantly. Moreover, the optimal PDT conditions for these bacteria were obtained through this in vitro screening and could guide the clinical PDT on periodontitis.http://www.worldscientific.com/doi/pdf/10.1142/S1793545815500170Photodynamic therapyperiodontitistoluidine blue Oendogenous photosensitizersurvival rate
collection DOAJ
language English
format Article
sources DOAJ
author Xuewei Jiang
Zhichao Fan
Yili Yu
Chenying Shao
Yuanzhen Suo
Xunbin Wei
Yi Zhou
spellingShingle Xuewei Jiang
Zhichao Fan
Yili Yu
Chenying Shao
Yuanzhen Suo
Xunbin Wei
Yi Zhou
Toluidine blue O and porphyrin-mediated photodynamic therapy on three main pathogenic bacteria of periodontitis using portable LED phototherapy device
Journal of Innovative Optical Health Sciences
Photodynamic therapy
periodontitis
toluidine blue O
endogenous photosensitizer
survival rate
author_facet Xuewei Jiang
Zhichao Fan
Yili Yu
Chenying Shao
Yuanzhen Suo
Xunbin Wei
Yi Zhou
author_sort Xuewei Jiang
title Toluidine blue O and porphyrin-mediated photodynamic therapy on three main pathogenic bacteria of periodontitis using portable LED phototherapy device
title_short Toluidine blue O and porphyrin-mediated photodynamic therapy on three main pathogenic bacteria of periodontitis using portable LED phototherapy device
title_full Toluidine blue O and porphyrin-mediated photodynamic therapy on three main pathogenic bacteria of periodontitis using portable LED phototherapy device
title_fullStr Toluidine blue O and porphyrin-mediated photodynamic therapy on three main pathogenic bacteria of periodontitis using portable LED phototherapy device
title_full_unstemmed Toluidine blue O and porphyrin-mediated photodynamic therapy on three main pathogenic bacteria of periodontitis using portable LED phototherapy device
title_sort toluidine blue o and porphyrin-mediated photodynamic therapy on three main pathogenic bacteria of periodontitis using portable led phototherapy device
publisher World Scientific Publishing
series Journal of Innovative Optical Health Sciences
issn 1793-5458
1793-7205
publishDate 2015-07-01
description Photodynamic therapy (PDT) has been commonly used in treating many diseases, such as cancer and infectious diseases. We investigated the different effects of PDT on three main pathogenic bacteria of periodontitis — Prevotella melaninogenica (P.m.), Porphyromonas gingivalis (P.g.) and Aggregatibacter actinomycetemcomitans (A.a.). The portable red light-emitting diode (LED) phototherapy device was used to assess the exogenous PDT effects with different light doses and photosensitizer concentrations (Toluidine blue O, TBO). The portable blue LED phototherapy device was used to assess the endogenous PDT effects with the use of endogenous photosensitizers (porphyrin) under different light doses. We found out that both exogenous and endogenous PDT were able to restrict the growth of all the three bacteria significantly. Moreover, the optimal PDT conditions for these bacteria were obtained through this in vitro screening and could guide the clinical PDT on periodontitis.
topic Photodynamic therapy
periodontitis
toluidine blue O
endogenous photosensitizer
survival rate
url http://www.worldscientific.com/doi/pdf/10.1142/S1793545815500170
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