Gender Differences in Neurodegeneration, Neuroinflammation and Na+-Ca2+ Exchangers in the Female A53T Transgenic Mouse Model of Parkinson’s Disease

Gender Differences in Neurodegeneration, Neuroinflammation and Na+-Ca2+ Exchangers in the Female A53T Transgenic Mouse Model of Parkinson’s Disease

Twelve-month-old male mice expressing the human A53T variant of α-synuclein (A53T) develop dopamine neuron degeneration, neuroinflammation, and motor deficits, along with dysfunctions of the mitochondrial Na+-Ca2+ exchanger (NCX) isoforms 1 (NCX1) and 3 (NCX3) in the nigrostriatal system. Since gend...

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Bibliographic Details
Main Authors: Giulia Costa, Maria Jose Sisalli, Nicola Simola, Salvatore Della Notte, Maria Antonietta Casu, Marcello Serra, Annalisa Pinna, Antonio Feliciello, Lucio Annunziato, Antonella Scorziello, Micaela Morelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
constipation
dopamine
GFAP
IBA-1
memory
midbrain
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00118/full

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