Gibbs Free Energy Calculation of Mutation in PncA and RpsA Associated With Pyrazinamide Resistance

A central approach for better understanding the forces involved in maintaining protein structures is to investigate the protein folding and thermodynamic properties. The effect of the folding process is often disturbed in mutated states. To explore the dynamic properties behind mutations, molecular...

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Bibliographic Details
Main Authors: Muhammad Tahir Khan, Sajid Ali, Muhammad Tariq Zeb, Aman Chandra Kaushik, Shaukat Iqbal Malik, Dong-Qing Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
GFE
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00052/full