MoSe₂-Au Based Sensitivity Enhanced Optical Fiber Surface Plasmon Resonance Biosensor for Detection of Goat-Anti-Rabbit IgG

• Main Authors: Kun Liu, Jiahang Zhang, Junfeng Jiang, Tianhua Xu, Shuang Wang, Pengxiang Chang, Zhao Zhang, Jinying Ma, Tiegen Liu
• Format: Article
• Language: English
• Published: IEEE 2020-01-01
• Series: IEEE Access
• Subjects: Surface plasmon resonance; optical fiber; MoSe₂; biosensor; Goat-anti-Rabbit IgG
• Online Access: https://ieeexplore.ieee.org/document/8939404/

Surface Plasmon resonance (SPR) provides an efficacious and label-free detection method for optical fiber bio-sensing. MoSe₂ is one of the transition metal dichalcogenides (TMDCs) which has broad applications in detecting specific reactions. Cysteamine hydrochloride with enriched groups can generate self-assemble films for tight attachment. In this study we aimed to combine the rapid response of optical fiber SPR sensors with the enhanced sensitivity of MoSe₂ nano-films. An optical fiber SPR biosensor with MoSe₂-Au nanostructure was proposed and implemented, and a sensitivity of 2821.81 nm/RIU was achieved, which was approximately 98.7% higher than that of conventional SPR sensor without using MoSe₂ nanostructure. Furthermore, Bovine Serum Albumin (BSA) was utilized as the target molecule to test the bioaffinity of the biosensor with MoSe₂ deposition cycles from 0 to 8. Weighing the sensitivity and the figure of merit (FOM), the best deposition cycle of MoSe₂ was 4 with the sensitivity of 2793.36 nm/RIU and FOM of 37.24 RIU^-1. At last, immunization experiments were carried out using Goat-anti-Rabbit IgG and a detection limit of 0.33 μg/mL was achieved. The rapid response and the high bioaffinity showed a strong applicability of the proposed MoSe₂-Au SPR immune-sensor in specific interactions and immunization therapy.