Antidepressant Effect and Recognition Memory Improvement of Two Novel Plant Extract Combinations - Antistress I and Anti-stress II on Rats Subjected to a Model of Mild Chronic Stress

• Main Authors: Kandilarov Ilin K., Zlatanova Hristina I., Georgieva-Kotetarova Maria T., Kostadinova Ivanka I., Katsarova Mariana N., Dimitrova Stela Z., Lukanov Ludmil K., Sadakov Ferit
• Format: Article
• Language: English
• Published: Pensoft Publishers 2018-03-01
• Series: Folia Medica
• Subjects: chronic stress; forced swim test; novel object recognition test; plant extract combinations; serratula coronata
• Online Access: http://www.degruyter.com/view/j/folmed.2017.60.issue-1/folmed-2017-0073/folmed-2017-0073.xml?format=INT

Background: Chronic stress is one of the main factors which lead to depression – a psychiatric disorder affecting millions of people and predicted to be the second ranked cause of premature death in 2020. Depression is often associated with cognitive disturbances and memory deficit. Plant based therapy could be effective in the treatment of mild to moderate depression due to its low level of adverse reaction, its good tolerability and compliance.