Pan-Influenza A Protection by Prime–Boost Vaccination with Cold-Adapted Live-Attenuated Influenza Vaccine in a Mouse Model

Pan-Influenza A Protection by Prime–Boost Vaccination with Cold-Adapted Live-Attenuated Influenza Vaccine in a Mouse Model

Influenza virus infections continually pose a major public health threat with seasonal epidemics and sporadic pandemics worldwide. While currently licensed influenza vaccines provide only strain-specific protection, antigenic drift and shift occasionally render the viruses resistant to the host immu...

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Bibliographic Details
Main Authors: Yo Han Jang, Joo Young Kim, Young Ho Byun, Ahyun Son, Jeong-Yoon Lee, Yoon Jae Lee, Jun Chang, Baik Lin Seong
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
influenza virus
cold-adapted live-attenuated vaccine
cross-protection
T cell
NK cell
antibody
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00116/full

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