Cyclooxygenase-2 Glycosylation Is Affected by Peroxynitrite in Endothelial Cells: Impact on Enzyme Activity and Degradation

Cyclooxygenase-2 Glycosylation Is Affected by Peroxynitrite in Endothelial Cells: Impact on Enzyme Activity and Degradation

The exposure of human endothelial cells to 3-morpholinosydnonimine (SIN-1) induced the expression of cyclooxygenase-2 (COX-2) in a dose- and time-dependent manner. Interestingly, after a prolonged incubation (>8 h) several proteoforms were visualized by Western blot, corresponding to different st...

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Bibliographic Details
Main Authors: Sonia Eligini, Susanna Colli, Aida Habib, Giancarlo Aldini, Alessandra Altomare, Cristina Banfi
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Antioxidants
Subjects:
cyclooxygenase-2
SIN-1
endothelial cell
N-linked glycosylation
Online Access:https://www.mdpi.com/2076-3921/10/3/496

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