Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity.

Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity.

Understanding the pathogenesis of infection by neurotropic viruses represents a major challenge and may improve our knowledge of many human neurological diseases for which viruses are thought to play a role. Borna disease virus (BDV) represents an attractive model system to analyze the molecular mec...

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Bibliographic Details
Main Authors: Christine M A Prat, Sonja Schmid, Fanny Farrugia, Nicolas Cenac, Gwendal Le Masson, Martin Schwemmle, Daniel Gonzalez-Dunia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2673689?pdf=render

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http://europepmc.org/articles/PMC2673689?pdf=render

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