HIV-derived ssRNA binds to TLR8 to induce inflammation-driven macrophage foam cell formation.

HIV-derived ssRNA binds to TLR8 to induce inflammation-driven macrophage foam cell formation.

Even though combined anti-retroviral therapy (cART) dramatically improves patient survival, they remain at a higher risk of being afflicted with non-infectious complications such as cardiovascular disease (CVD). This increased risk is linked to persistent inflammation and chronic immune activation....

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Bibliographic Details
Main Authors: Mark A Bernard, Xinbing Han, Sonya Inderbitzin, Ifunanya Agbim, Hui Zhao, Henry Koziel, Souvenir D Tachado
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4121254?pdf=render

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