Targeted DNA vaccines for enhanced induction of Idiotype (Id)-specific B and T cells

Targeted DNA vaccines for enhanced induction of Idiotype (Id)-specific B and T cells

Background: Idiotopes (Id) are antigenic determinants localized in variable (V) regions of Ig. Id-specific T and B cells (antibodies) play a role in immunotherapy of Id+ tumors. However, vaccine strategies that enhance Id-specific responses are needed. Methods: Id+ single chain Fragment variable (sc...

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Bibliographic Details
Main Authors: Agnete Brunsvik Fredriksen, Inger eSandlie, Bjarne eBogen
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-10-01
Series:Frontiers in Oncology
Subjects:
Lymphoma
Multiple Myeloma
Vaccine
antigen presenting cells
Idiotype
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00154/full

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