Microglia Express Mu Opioid Receptor: Insights From Transcriptomics and Fluorescent Reporter Mice

Microglia Express Mu Opioid Receptor: Insights From Transcriptomics and Fluorescent Reporter Mice

Background: Microglia activation contributes to chronic pain and to the adverse effects of opiate use such as analgesic tolerance and opioid-induced hyperalgesia. Both mu opioid receptor (MOR) encoded by Oprm1/OPRM1 gene and toll like receptor 4 (TLR4) have been reported to mediate these morphine ef...

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Bibliographic Details
Main Authors: Tando Maduna, Emilie Audouard, Doulaye Dembélé, Nejma Mouzaoui, David Reiss, Dominique Massotte, Claire Gaveriaux-Ruff
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Psychiatry
Subjects:
microglia
opioid receptor
mu
transcriptomics
gene clusters
fluorescent reporter mice
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2018.00726/full

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