Statistical Properties of Protein-Protein Interfaces

Statistical Properties of Protein-Protein Interfaces

The properties of 1172 protein complexes (downloaded from the Protein Data Bank (PDB)) have been studied based on the concept of circular variance as a buriedness indicator and the concept of mutual proximity as a parameter-free definition of contact. The propensities of residues to be in the protei...

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Main Author: Mihaly Mezei
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Algorithms
Subjects:
accessible surface
circular variance
mutual proximity
residue propensity
Online Access:http://www.mdpi.com/1999-4893/8/2/92
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spelling doaj-b2360b059c17481c9ad78ed03c78839a2020-11-24T21:28:02ZengMDPI AGAlgorithms1999-48932015-04-0182929910.3390/a8020092a8020092Statistical Properties of Protein-Protein InterfacesMihaly Mezei0Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USAThe properties of 1172 protein complexes (downloaded from the Protein Data Bank (PDB)) have been studied based on the concept of circular variance as a buriedness indicator and the concept of mutual proximity as a parameter-free definition of contact. The propensities of residues to be in the protein, on the surface or form contact, as well as residue pairs to form contact were calculated. In addition, the concept of circular variance has been used to compare the ruggedness and shape of the contact surface with the overall surface.http://www.mdpi.com/1999-4893/8/2/92accessible surfacecircular variancemutual proximityresidue propensity
collection DOAJ
language English
format Article
sources DOAJ
author Mihaly Mezei
spellingShingle Mihaly Mezei
Statistical Properties of Protein-Protein Interfaces
Algorithms
accessible surface
circular variance
mutual proximity
residue propensity
author_facet Mihaly Mezei
author_sort Mihaly Mezei
title Statistical Properties of Protein-Protein Interfaces
title_short Statistical Properties of Protein-Protein Interfaces
title_full Statistical Properties of Protein-Protein Interfaces
title_fullStr Statistical Properties of Protein-Protein Interfaces
title_full_unstemmed Statistical Properties of Protein-Protein Interfaces
title_sort statistical properties of protein-protein interfaces
publisher MDPI AG
series Algorithms
issn 1999-4893
publishDate 2015-04-01
description The properties of 1172 protein complexes (downloaded from the Protein Data Bank (PDB)) have been studied based on the concept of circular variance as a buriedness indicator and the concept of mutual proximity as a parameter-free definition of contact. The propensities of residues to be in the protein, on the surface or form contact, as well as residue pairs to form contact were calculated. In addition, the concept of circular variance has been used to compare the ruggedness and shape of the contact surface with the overall surface.
topic accessible surface
circular variance
mutual proximity
residue propensity
url http://www.mdpi.com/1999-4893/8/2/92
work_keys_str_mv AT mihalymezei statisticalpropertiesofproteinproteininterfaces
_version_ 1725972004094345216

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