Chronic heart failure serum S100B level and its short-term clinical significance
Objective: To explore the clinical significance of serum S100B in chronic heart failure (CHF). Methods: A total of 300 patients with CHF of cardiac function levels II–IV were divided into three groups, and 300 normal cases were selected as controls. Serum S100B, B-type natriuretic peptide (BNP),...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2019-03-01
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| Series: | Journal of Hainan Medical University |
| Online Access: | http://www.hnykdxxb.com/PDF/201906/07.pdf |
| Summary: | Objective: To explore the clinical significance of serum S100B in chronic heart failure (CHF).
Methods: A total of 300 patients with CHF of cardiac function levels II–IV were divided
into three groups, and 300 normal cases were selected as controls. Serum S100B, B-type
natriuretic peptide (BNP), LVEF(%) and LVEDD were detected and analyzed. CHF patients
were followed up for 1 year. Statistical analysis was performed using SPSS and Microsoft
Excel. Results: The level of S100B in CHF patients was significantly increased, and the serum
level was positively correlated with BNP. The serum S100B level was positively correlated
with heart failure classification, and the area under ROC curve was 0.84. The sensitivity and
specificity were 81.2% and 71.5%, respectively. Patients with high serum S100B were at
higher risk of major cardiovascular events. Conclusion: Serum S100B level is significantly
increased in patients with chronic heart failure, and is negatively correlated with the patients’
cardiac function. It is an independent risk factor for the occurrence and development of chronic
heart failure, and it has implications for the prognosis of patients with chronic heart failure. |
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| ISSN: | 1007-1237 1007-1237 |