Transcriptomic Analysis of HCN-2 Cells Suggests Connection among Oxidative Stress, Senescence, and Neuron Death after SARS-CoV-2 Infection

Transcriptomic Analysis of HCN-2 Cells Suggests Connection among Oxidative Stress, Senescence, and Neuron Death after SARS-CoV-2 Infection

According to the neurological symptoms of SARS-CoV-2 infection, it is known that the nervous system is influenced by the virus. We used pediatric human cerebral cortical cell line HCN-2 as a neuronal model of SARS-CoV-2 infection, and, through transcriptomic analysis, our aim was to evaluate the eff...

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Bibliographic Details
Main Authors: Andrea Valeri, Luigi Chiricosta, Valeria Calcaterra, Mara Biasin, Gioia Cappelletti, Stephana Carelli, Gian Vincenzo Zuccotti, Placido Bramanti, Gloria Pelizzo, Emanuela Mazzon, Agnese Gugliandolo
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
oxidative stress
ROS homeostasis
cell cycle
apoptosis
HCN-2
SARS-CoV-2
Online Access:https://www.mdpi.com/2073-4409/10/9/2189

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