Identification of novel enriched recurrent chimeric COL7A1-UCN2 in human laryngeal cancer samples using deep sequencing

Identification of novel enriched recurrent chimeric COL7A1-UCN2 in human laryngeal cancer samples using deep sequencing

Abstract Background As hybrid RNAs, transcription-induced chimeras (TICs) may have tumor-promoting properties, and some specific chimeras have become important diagnostic markers and therapeutic targets for cancer. Methods We examined 23 paired laryngeal cancer (LC) tissues and adjacent normal mucou...

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Bibliographic Details
Main Authors: Ye Tao, Neil Gross, Xiaojiao Fan, Jianming Yang, Maikun Teng, Xu Li, Guojun Li, Yang Zhang, Zhigang Huang
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Cancer
Subjects:
Laryngeal cancer
Transcription-induced chimera
Gene fusion
COL7A1
UCN2
Online Access:http://link.springer.com/article/10.1186/s12885-018-4161-8

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