Spray Drying for Direct Compression of Pharmaceuticals

• Main Authors: Nizar Al-Zoubi, Shadi Gharaibeh, Ahmad Aljaberi, Ioannis Nikolakakis
• Format: Article
• Language: English
• Published: MDPI AG 2021-01-01
• Series: Processes
• Subjects: spray drying; direct compression; tablets; co-processing; multifunctional; sustained release
• Online Access: https://www.mdpi.com/2227-9717/9/2/267

Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and excipients lack the compression and flow properties required to meet the needs of high-speed industrial tablet presses. Therefore, the majority of DC APIs and excipients are modified via processing/co-processing particle engineering techniques to boost their properties. Spray drying is one of the most commonly employed techniques to prepare DC grades of APIs and excipients with prominent advantages. This review aims to present an overview of the commercially marketed and investigationally-prepared DC APIs and excipients produced by spray drying.