Deletion of the murine ortholog of the 8q24 gene desert has anti-cancer effects in transgenic mammary cancer models

Deletion of the murine ortholog of the 8q24 gene desert has anti-cancer effects in transgenic mammary cancer models

Abstract Background The gene desert on human chromosomal band 8q24 harbors multiple genetic variants associated with common cancers, including breast cancer. The locus, including the gene desert and its flanking genes, MYC, PVT1 and FAM84B, is also frequently amplified in human breast cancer. We gen...

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Bibliographic Details
Main Authors: Collin Homer-Bouthiette, Yang Zhao, Lauren B. Shunkwiler, Benjamine Van Peel, Elizabeth Garrett-Mayer, Rachael C. Baird, Anna I. Rissman, Stephen T. Guest, Stephen P. Ethier, Manorama C. John, Patricia A. Powers, Jill D. Haag, Michael N. Gould, Bart M. G. Smits
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Cancer
Subjects:
Breast cancer susceptibility
Noncoding
SNP
Risk
GWAS
Murine
Online Access:http://link.springer.com/article/10.1186/s12885-018-5109-8

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