iPSC-Derived Microglia for Modeling Human-Specific DAMP and PAMP Responses in the Context of Alzheimer’s Disease

iPSC-Derived Microglia for Modeling Human-Specific DAMP and PAMP Responses in the Context of Alzheimer’s Disease

Neuroinflammation in Alzheimer’s disease (AD) has been the focus for identifying targetable pathways for drug development. The role of amyloid beta (Aβ), a prototype of damage-associated molecular patterns (DAMPs), has been implicated in triggering an inflammatory response. As alpha7 nicotinic acety...

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Bibliographic Details
Main Authors:	Ivanna Ihnatovych, Barbara Birkaya, Emily Notari, Kinga Szigeti
Format:	Article
Language:	English
Published:	MDPI AG 2020-12-01
Series:	International Journal of Molecular Sciences
Subjects:	CHRFAM7A neuroinflammation Alzheimer’s disease NF-κB activation cholinergic anti-inflammatory response DAMPs
Online Access:	https://www.mdpi.com/1422-0067/21/24/9668

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